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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: Cellular function reinstitution of offspring red blood cells cloned from the sickle cell disease patient blood post CRISPR genome editing

Fig. 5

Comparison of CRISPR genome editing using Cas9 protein or Cas9 mRNA. a Scheme depicting CRISPR using Cas9 protein with a single electroporation vs. Cas9 mRNA with repeated electroporation steps. b E- and G/M-colonies formed on Methocult from unmanipulated HSPCs, CRISPR genome-edited HSPCs mediated with Cas9 protein, and CISPR genome-edited HSPCs mediated with Cas9 mRNA. *p ≤ 0.05. c The efficacy of CRISPR genome editing mediated with Cas9 protein or Cas9 mRNA

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