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Fig. 7 | Journal of Hematology & Oncology

Fig. 7

From: Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia

Fig. 7

Blimp-1 positively regulates the expression of PD-1 and TIGIT. a Purified CD4+ and CD8+ T cells from AML patients (n = 3) were transfected with indicated siRNA. Expression of mRNA for Blimp-1, PD-1, TIGIT, and BCL-6 upon Blimp-1 knockdown was assessed by real-time PCR. b MT4 cells were transfected with PRDM1α and PRDM1β plasmids for 48 h. The mRNA levels of Blimp-1, PD-1, TIGIT, and BCL6 were quantified by real-time PCR. Values were normalized to those of GAPDH and expressed relative to negative control. P values were obtained by unpaired t test.

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