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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Targeting VEGFR-3/-2 signaling pathways with AD0157: a potential strategy against tumor-associated lymphangiogenesis and lymphatic metastases

Fig. 3

AD0157 prevents distant metastases. a Representative ex vivo bioluminescent signals of distant organs (brain, lungs, liver, intestines, kidneys, spleen, and uterus). b Immunohistochemical images visualizing micrometastases by human Ki-67 detection (in brown). Scale bars represent 250 μm. c Number and percentage of organs colonized by metastatic cells. Data are presented as mean ± s.e.m., and the Wilcoxon-Mann-Whitney significance tests were used to compare the differences between vehicle (control) and AD0157 treatment. Chi-square with Yates’ correction test was used to analyze the metastasis incidence. *p < 0.05, **p < 0.01, ***p < 0.001 (n = 12 mice/group)

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