Fig. 1
Study flow chart. During the study period, 276 patients were screened for eligibility, and 261 patients met the inclusion criteria. Among them, 127 patients showed thrombocytopenia, of which 113 severe sepsis patients with platelet count less than 50 × 109/L were eligible for the subsequent randomized trial phase. Of them, 110 consented to participate in this phase and were randomly assigned to either receive antimicrobial therapy alone or to receive antimicrobial therapy plus oseltamivir