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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: The chimeric monoclonal antibody MHCSZ-123 against human von Willebrand factor A3 domain inhibits high-shear arterial thrombosis in a Rhesus monkey model

Fig. 3

MHCSZ-123 blocked binding of Rhesus monkey VWF to human collagen type III. a Binding curve of Rhesus monkey VWF binding to collagen. b Inhibition of Rhesus monkey VWF to collagen. MHCSZ-123 and SZ-123 (2–128 μg/mL) were tested for blocking interactions between Rhesus monkey VWF and human type III collagen coated on plates. The percent inhibition was similar to the parent mAb SZ-123. mAb SZ-34, a non-blocking mAb to the human VWF A2 domain, was used as a negative control. Data are presented as mean ± SD (n = 6 animals)

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