Fig. 5

TP53, PDGFBA, BRAF, ERBB2, CTNNB1, EGFR, and ARID1A mutations present in minor clones in the primary tumors are detectable in plasma ctDNA. The X axis represents allele variant fractions. Each circle represents one gene mutation present in tumor tissues as examined by Foundation1 test (F). The cases presented manifest heterogeneity and multiple clonal characteristics. Mutations also found in Guardant360 test (G) are indicated by red circle. The order of the two tests and whether the patient was treated (Tx1 for yes and Tx0 for no) is shown in the right panel