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Table 2 Trabectedin plus rucaparib combination study: combination index according to Chou and Talalay

From: Activity of trabectedin and the PARP inhibitor rucaparib in soft-tissue sarcomas

Cell lines

Combination index

Comments

IB114

0.64

Synergistic

IB115

0.75

Synergistic

IB111

0.71

Synergistic

IB133

1.17

Antagonist

IB134

1.02

Additive

IB136

1.18

Antagonist

IB112

0.99

Additive

IB128

0.92

Additive

93T449

0.86

Synergistic