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Table 2 Mutations in CD19+, CD34+CD19−, CD3+ and CD14+ PB cell populations identified by ultra-deep NGS

From: Next-generation sequencing and FISH studies reveal the appearance of gene mutations and chromosomal abnormalities in hematopoietic progenitors in chronic lymphocytic leukemia

    

Time point 1; bone narrow

Time point 2: peripheral blood

Patient ID

IGHV mutation status

Mutated gene

AA change

%mut CD19

%mut CD34

%mut CD19+

%mut CD34+CD19−

%mut CD3+

%mut CD14+

13

Mutated

MYD88

p.M232T

36

22

23.1

12.2

2.6

7.7

31

Mutated

NOTCH1

p.P2514Rfs*4

4

< 10

15.3

2.1

0

0

36

Mutated

FBXW7

p.R465L

39

< 10

3.2

3.0

2.7

3.6

37

Unmutated

XPO1

p.E571K

51

38

53.0

3.0

3.0

0.4

42

Unmutated

NOTCH1

p.P2514Rfs*4

5.25

< 10

33.0

12.9

0

0.6

50

Unmutated

SF3B1

p.R625H

21

< 10

15.0

1.0

0.1

0.1

50

Unmutated

FBXW7

p.G423V

8

< 10

0

0

0

0

57

Mutated

FBXW7

p.R465H

42

13

46.5

2.4

0.8

2.6

  1. The cut-off set for the second time point was 2% (bold) provided that our FACS purities were higher than 98% in all cases for all cell populations
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Journal of Hematology & Oncology

ISSN: 1756-8722

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