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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma

Fig. 1

IQS019 simultaneously targets Syk, Lyn and Btk tyrosine kinases and blocks cell proliferation in distinct subtypes of B lymphoid neoplasms. a Chemical structure of IQS019. b Selectivity kinase inhibition profile of IQS019 against tyrosine kinase (TK) and tyrosine kinase-like (TKL), when compared to the other subfamilies of protein kinases (*** p < 0.001). c Effect of IQS019 on the proliferation of control (parental), Syk-, Lyn-, and Btk-overexpressing Ba/F3 cells. The different cell lines were treated with increasing dose of IQS019 and proliferation blockade was assessed by MTT assay, using untreated cells as a reference. Measured data represent the activities of duplicate determinations. d Effect of IQS019 on the proliferation of CLL primary cultures. Cells (2 x 105) were incubated with increasing concentrations of IQS019 for 24 hours and cell viability was determined by the MTT reduction assay. Results are the mean values ± SD of four replicates, and are referred to control, untreated cells

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