Skip to main content

Advertisement

Table 2 Univariate and multivariate analyses of clinicopathological characteristics, miR-195-5p, and YAP1 with overall survival in TCGA COAD cohort and independent validation cohort

From: Integrated analysis identifies microRNA-195 as a suppressor of Hippo-YAP pathway in colorectal cancer

  Univariate analysisa Multivariate analysisb
HR (95% Cl) P value HR (95% CI) P value
TCGA COAD testing set (n = 240)
 Gender(male vs. female) 1.938(1.0653.526) 0.030 2.512(1.3214.775) 0.005
 Age, years (≥median vs. < median) 1.591(0.843–3.003) 0.152   
 Nodes count (12 or more vs. fewer than 12) 0.726(0.402–1.309) 0.287   
 Lymphatic invasion (present vs. absent) 2.171(1.2383.809) 0.007 1.453(0.572–3.694) 0.432
 Pathologic M stage (present vs. absent) 3.060(1.6525.667) 0.001 1.969(0.9883.924) 0.034
 TNM stage (III and IV vs. I and II) 2.099(1.1853.717) 0.011 1.206(0.573–2.536) 0.622
 Vascular invasion (present vs. absent) 2.400(1.3184.372) 0.004 1.660(0.719–3.830) 0.235
 Preoperative CEA level (≥5 μg/mL vs. <5 μg/mL) 0.982(0.542–1.780) 0.953   
 Hsa-miR-195 (≥median vs. < median) 0.488(0.2620.910) 0.023 0.419(0.2140.819) 0.011
 YAP1 (≥median vs. < median) 2.022(1.1203.652) 0.019 1.379(0.714–2.664) 0.339
Independent validation cohort (n = 60)
 Gender(male vs. female) 0.879(0.494–1.564) 0.661   
 Age, years (≥median vs. < median) 0.823(0.458–1.478) 0.514   
 Nodes count (12 or more vs. fewer than 12) 1.323(0.724–2.418) 0.363   
 Lymphatic invasion (present vs. absent) 1.542(0.852–2.790) 0.153   
 Pathologic M stage (present vs. absent) 16.910(5.79349.361) <0.001 4.140(2.8255.442) 0.001
 TNM stage (III and IV vs. I and II) 1.542(0.852–2.789) 0.153   
 Vascular invasion (present vs. absent) 1.060(0.541–2.075) 0.866   
 Preoperative CEA level (≥5 μg/mL vs. <5 μg/mL) 0.893(0.506-1.573) 0.695   
 Hsa-miR-195 (≥median vs. < median) 0.526(0.2940.941) 0.031 0.704(0.3440.875) 0.044
 YAP1 (≥median vs. < median) 1.969(1.0923.547) 0.024 1.476(0.623–3.497) 0.377
  1. aThe data were subjected to Cox’s proportional hazards regression model. Bold italics indicate statistically significant values (P < 0.05)
  2. bMultivariate analysis used stepwise addition and removal of clinical covariates found to be associated with survival in univariate models (P < 0.05) and final models include only those covariates that were significantly associated with survival (Wald statistic, P < 0.05). Bold italics indicate statistically significant values (P < 0.05)