Fig. 3

Expressions of miR-195-5p and YAP1 are inversely correlated in primary CRC tumors. a Expression of miR-195-5p in two colon cancer cell lines, DLD1 and HCT116, and the normal NCM460 cells. Assays were performed in triplicates. b MiR-195-5p is significantly decreased in primary human CRC tissues compared with PANT. Mean ± SD is shown. Statistical analysis was conducted using Student's t test. c Kaplan–Meier curves of the overall survivals (OS) reveal that downregulated miR-195-5p is associated with poor prognosis in CRC patients. P value was obtained by a log-rank test. d YAP1 mRNA and protein levels are shown for the CRC tissues and PANT. e Scatter plots showing the inverse association between miR-195-5p and YAP1 mRNA levels. f Kaplan–Meier analysis of OS based on YAP1 mRNA levels in 60 cases of CRC patients