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Table 1 Tumor-associated antigens of CAR-T cell target

From: Chimeric antigen receptor T cells: a novel therapy for solid tumors

Antigen Full name Disease
EGFR Epidermal growth factor receptor NSCLC, epithelial carcinoma, glioma
EGFRvIII Variant III of the epidermal growth factor receptor Glioblastoma
HER2 Human epidermal growth factor receptor 2 Ovarian cancer, breast cancer, glioblastoma, colon cancer, osteosarcoma, medulloblastoma
MSLN Mesothelin Mesothelioma, ovarian cancer, pancreatic adenocarcinoma
PSMA Prostate-specific membrane antigen Prostate cancer
CEA Carcinoembryonic antigen Pancreatic adenocarcinoma, breast cancer, colorectal carcinoma
GD2 Disialoganglioside 2 Neuroblastoma, melanoma
IL13Rα2 Interleukin-13Ra2 Glioma
GPC3 Glypican-3 Hepatocellular carcinoma
CAIX Carbonic anhydrase IX Renal cell carcinoma (RCC)
L1-CAM L1 cell adhesion molecule Neuroblastoma, melanoma, ovarian adenocarcinoma
CA125 Cancer antigen 125 (also known as MUC16) Epithelial ovarian cancers
CD133 Cluster of differentiation 133 (also known as prominin-1) Glioblastoma, cholangiocarcinoma (CCA)
FAP Fibroblast activation protein Malignant pleural mesothelioma (MPM)
CTAG1B Cancer/testis antigen 1B (also known as NY-ESO-1) Melanoma and ovarian cancer
MUC1 Mucin 1 Seminal vesicle cancer
FR-α Folate receptor-α Ovarian cancer