Fig. 5
From: The cell cycle checkpoint inhibitors in the treatment of leukemias
Schematic representation of the mechanism of action of the WEE1 inhibitor. In both normal and tumor cells, the activation of WEE1 upon induction of DNA damage is not fully understood. WEE1 phosphorylates both CDK1/CDK2 to prevent the constitution of the complexes CDK/cyclins. Inhibition of WEE1 activity prevents the phosphorylation of CDKs and impairs the cell cycle checkpoint after DNA damage induction. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents