Fig. 8
Oral administration of PS prevents lung-colonization of intravenously inoculated tumor cells and suppresses the growth of already established tumor nodules in the lungs. a Tumor nodules in the lungs of the sacrificed mice who orally received DMSO vehicle or 5 mg/kg of PS (twice/day) from before to after (before and after) or 5 days after (after) intravenously inoculation of 5 × 105 LLC cells that were recovered in 20% FBS/DMEM for 2 h at 37 °C. The mice were sacrificed 30 days after tumor injection. b Representative mouse lungs with tumor nodules and their H&E staining from the mice as described in (a). c Microscopies of the H&E staining of mouse lungs as described in (b). Note: * means p value <0.05. Red lines in the magnitudes of 40×, 100×, and 400× mean 200, 100, and 20 μm, respectively. Arrow heads mean the tumor nodules in the lungs. Arrows mean the apparent apoptotic tumor cells with fragmented DNAs