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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia

Fig. 4

Cell death synergism of m15-IgG1 antibody with components of standard of care (SOC) in CLL. The primary leukemia CLL-B cells were incubated either alone or with stroma-NK-tert cells and treated with m15-IgG1 (200 nM) and three different concentrations of SOC agents a rituximab (1, 3, and 10 μg/mL), b ibrutinib (0.1, 10, and 30 μM), c bendamustine (0.1, 30, and 90 μM), and d fludarabine (F-ara-A, 1, 3, and 10 μM). Treatments were performed with each agent alone or in combination. The % cell death was used to calculate the median effect of the combinatorial effect of m15-IgG1 with each different SOC agent. The synergism between m15-IgG1 and SOCs was expressed as a combination index (CI), which uses the definitions: additive (CI = 1), synergistic (CI < 1), and antagonistic (CI > 1). The data were analyzed. The empty circle symbols (O) denote CLL cells alone, while solid black symbols (■) denote CLL cells co-cultured with stroma-NK-tert cells

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