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Table 1 miRNAs implicated in T-ALL biology

From: T-ALL and thymocytes: a message of noncoding RNAs

 

miRBase release 21

Function

Direct targets

Refs

miR-19a

hsa-miR-19a-3p

ONC

CYLD

[120, 137]

ETP low

miR-19b

hsa-miR-19b-3p

ONC

BIM, CYLD, PP2A, PRKAA1, PTEN

[119–121]

miR-20a

hsa-miR-20a-5p

ONC

BIM, PHF6, PTEN

[121]

miR-21

hsa-miR-21-5p

ONC

PDCD4

[101]

miR-26a

hsa-miR-26a-5p

ONC

BIM, PHF6, PTEN

[121]

miR-29

hsa-miR-29a-3p

TSG

HBP1

[129]

miR-30a

hsa-miR-30a-5p/3p

MYC repressed

NOTCH1

[139, 140]

 

Targets NOTCH1

miR-31

hsa-miR-31-5p

TSG

HBP1

[130]

miR-92

hsa-miR-92a-3p

ONC

BIM, FBXW7, IKZF1, NF1, PTEN

[121]

miR-101

hsa-miR-101-3p

Targets TAL1

TAL1

[142]

miR-128-3p

hsa-miR-128-3p

ONC

PHF6

[99]

miR-140-5p

hsa-miR-140-5p

Targets TAL1

TAL1

[142]

miR-142-3p

hsa-miR-142-3p

ONC

cAMP, GRα, PKA

[125]

miR-146b-5p

hsa-miR-146b-5p

TAL1 repressed

–

[123]

miR-149*

hsa-miR-149-3p

ONC

JunB

[126]

miR-150

hsa-miR-150-5p

TSG

MYB

[130]

miR-155

hsa-miR-155-5p

TSG

HBP1, MYB

[130]

miR-181a

hsa-miR-181a-5p

ONC

EGR1, NRARP

[128]

miR-193b-3p

hsa-miR-193b-3p

TSG

MYB

[131]

TAL-R low

miR-196a

hsa-miR-196a-5p

IMM high

ERG

[135]

miR-196b

hsa-miR-196b-5p

HOXA high

ERG

[134, 135]

IMM high

miR-200c

hsa-miR-200c-3p

TSG

HBP1, MYB

[130]

miR-204

hsa-miR-204-5p

TSG

SOX4

[132]

miR-221

hsa-miR-221-3p

ETP high

–

[137]

miR-222

hsa-miR-222-3p

ETP high

ETS1

[137]

miR-223

hsa-miR-223-3p

ONC

FBXW7

[121–124, 136]

Myeloid high

TAL-R high

NOTCH1 activated

TAL1 activated

miR-363

hsa-miR-363-3p

ETP low

–

[137]

miR-448

hsa-miR-448

Targets TAL1

TAL1

[142]

miR-451

hsa-miR-451a

NOTCH1 repressed

c-MYC

[138]

miR-485-5p

hsa-miR-485-5p

Targets TAL1

TAL1

[142]

miR-520d-5p

hsa-miR-520d-5p

Targets TAL1

TAL1

[142]

miR-590

hsa-miR-590-5p

ONC

RB1

[127]

miR-92

hsa-miR-92a-3p

ONC

BIM, FBXW7, IKZF1, NF1, PTEN

[121]

  1. The most recent miRBase annotation was retrieved using the miRBase Tracker, www.mirbasetracker.org [160]
  2. ONC oncogenic miRNA, TSG tumor suppressor miRNA, ETP ETP-ALL, TAL-R TAL-rearranged T-ALL, IMM immature T-ALL, HOXA HOXA-overexpressing T-ALL