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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: A hybrid of B and T lymphoblastic cell line could potentially substitute dendritic cells to efficiently expand out Her-2/neu-specific cytotoxic T lymphocytes from advanced breast cancer patients in vitro

Fig. 2

The expanded Her2/neu-specific CTLs well recognize and kill the related targets. a The expanded effector cells (HER-2/neu(369–377)-or HER-2/neu(435–443)-specific CD8+ T cells) could only lyse HLA-A2-positive and Her-2/neu-overexpressed breast cancer cell line SK.BR.3, but not the controls. b Perforin or granzyme B secretion by expanded Her2/neu-specific effector cells was detected after co-culture with SK.BR.3. c Anti-HLA class I antibody blocking inhibited the cytotoxic activity of the expanded Her-2/neu-specific CD8+ T cells against SK.BR.3. Mouse IgG2 antibody was added as a control. *P < 0.05, **P < 0.01, ***P < 0.001 (ANOVA)

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Journal of Hematology & Oncology

ISSN: 1756-8722

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