Fig. 1

Increased YAP1 expression is associated with colon cancer malignancy. a Using public database, we first found that YAP1 mRNA expression is elevated (at least 2-fold increase) in colorectal adenoma samples as compared to normal tissues (Sabates-Bellver database). b Another database (Kaiser Colon database) indicated that YAP1 mRNA was significantly increased in a cohort of colon adenocarcinoma samples. c An increased YAP1 protein expression profile was supported by clinical sample database (i, Antibody CAB009370, ProteinAtlas.org); ii. Our immunohistochemical analysis also showed that YAP1 expression in normal colon crypts and a significantly increased YAP1 expression was found in the rectal adenocarcinoma section. The number indicates the area of magnified view. d YAP1 expression was also found to be associated significantly to time of disease recurrence [19]. e Patients with higher risk for colon cancer demonstrate both high YAP1 and IL-6 expression (upper panel); patients with combined high expression of IL-6 and YAP1 were found to be associated with a significantly lower specific survival rate (Colon Metabase, SurvExpress). P values are indicated in each panel