| Total number of patients | Age group | Genetics at diagnosis | Number of patients with gain of mutation | Number of patients with loss of mutation | Reference |
---|---|---|---|---|---|---|
FLT3-ITD | ||||||
Total | 492 | Â | Â | 38 | 25 | Â |
28 | A | Â | 1 | 1 | [65] | |
28 | A | Â | 6 | 1 | [77] | |
34 | A | Â | 2 | 3 | [76] | |
108 | A | Â | 8 | 1 | [81] | |
31 | A | Â | 1 | 2 | [85] | |
53 | A | NPM1 m | 9 | 3 | [69] | |
80 | A, P | Â | 5 | 4 | [79] | |
44 | A, P | Â | 2 | 5 | [80] | |
23 | P | Â | 2 | 1 | [84] | |
63 | P | Â | 2 | 4 | [83] | |
FLT3-TKD | ||||||
Total | 385 | Â | Â | 10 | 24 | Â |
34 | A | Â | 1 | 3 | [76] | |
120 | A | Â | 6 | 8 | [82] | |
31 | A | Â | 0 | 1 | [85] | |
53 | A | NPM1 m | 0 | 10 | [69] | |
53 | A, P | Â | 0 | 1 | [79] | |
44 | A, P | Â | 2 | 0 | [80] | |
50 | P | Â | 1 | 1 | [83] | |
NPM1 | ||||||
Total | 299 | Â | Â | 0 | 9 | Â |
28 | A | Â | 0 | 0 | [65] | |
34 | A | Â | 0 | 3 | [76] | |
53 | A | NPM1 m | n.a. | 5 | [69] | |
70 | A, P | NPM1 m | n.a. | 0 | [124] | |
46 | P | Â | 0 | 0 | [125] | |
68 | P | Â | 0 | 1 | [83] | |
DNMT3A | ||||||
Total | 231 | Â | Â | 1 | 2 | Â |
28 | A | Â | 0 | 0 | [65] | |
34 | A | Â | 0 | 0 | [76] | |
116 | A | Â | 0 | 1 | [87] | |
53 | A | NPM1 m | 1 | 1 | [69] | |
CEBPA | ||||||
Total | 241 | Â | Â | 2 | 5 | Â |
28 | A | Â | 1 | 1 | [65] | |
34 | A | Â | 0 | 2 | [76] | |
149 | A, P | Â | 0 | 2 | [86] | |
30 | P | Â | 1 | 0 | [83] | |
IDH2 | ||||||
Total | 236 | Â | Â | 0 | 1 | Â |
28 | A | Â | 0 | 0 | [65] | |
34 | A | Â | 0 | 0 | [76] | |
121 | A | Â | 0 | 0 | [126] | |
53 | A | NPM1 m | 0 | 1 | [69] | |
IDH1 | ||||||
Total | 115 | Â | Â | 4 | 2 | Â |
28 | A | Â | 0 | 0 | [65] | |
34 | A | Â | 0 | 0 | [76] | |
53 | A | NPM1 m | 4 | 2 | [69] | |
NRAS | ||||||
Total | 106 | Â | Â | 8 | 12 | Â |
19 | A | Â | 2 | 3 | [77] | |
34 | A | Â | 1 | 0 | [76] | |
53 | A | NPM1 m | 5 | 9 | [69] | |
KRAS | ||||||
Total | 62 | Â | Â | 1 | 1 | Â |
28 | A | Â | 0 | 1 | [65] | |
34 | A | Â | 1 | 0 | [76] | |
RAS | ||||||
Total | 75 | Â | Â | 6 | 8 | Â |
23 | P | Â | 2 | 1 | [84] | |
52 | P | Â | 4 | 7 | [83] | |
TP53 | ||||||
Total | 104 | Â | Â | 3 | 1 | Â |
28 | A | Â | 0 | 1 | [77] | |
23 | A | Â | 2 | 0 | [78] | |
53 | A | NPM1 m | 1 | 0 | [69] | |
WT1 | ||||||
Total | 104 | Â | Â | 14 | 0 | Â |
23 | P | Â | 3 | 0 | [84] | |
42 | P | Â | 5 | 0 | [83] | |
39 | P | Â | 6 | 0 | [127] | |
ASXL1 | ||||||
Total | 81 | Â | Â | 2 | 0 | Â |
28 | A | Â | 0 | 0 | [65] | |
53 | A | NPM1 m | 2 | 0 | [69] | |
KIT | ||||||
Total | 35 | Â | Â | 0 | 0 | Â |
27 | P | Â | 0 | 0 | [83] | |
8 | P | CBF | 0 | 0 | [128] | |
TET2 | ||||||
Total | 62 | Â | Â | 0 | 0 | Â |
28 | A | Â | 0 | 0 | [65] | |
34 | A | Â | 0 | 0 | [76] | |
MLL-PTD | ||||||
 | 34 | A |  | 0 | 0 | [76] |
PTPN11 | ||||||
 | 23 | P |  | 0 | 1 | [84] |
RUNX1 | ||||||
 | 28 | A |  | 1 | 1 | [65] |