Fig. 2

Circos plot summarizing genetic aberrations recurrently acquired at relapse in adult patients with non-APL AML. Inner circle, unbalanced cytogenetic aberrations newly acquired at relapse in at least 2 patients [53–56, 63, 68, 122]; middle circle, CNAs and UPDs newly acquired at relapse in at least 2 patients [64–69]. Within each type of aberration, overlapping lesions were considered recurrent events unless an aberration was reported only in 1 patient and became recurrent due to the same type of aberration affecting the corresponding entire chromosome in another single patient. For high patient numbers, different scales were used and patient numbers color-coded as indicated in the graphical legend. Outer circle, genes affected by SNVs or indels in a relapse-specific manner in at least 2 patients according to next generation sequencing-based studies [34, 36, 38, 39, 68, 95, 96]. The plot was constructed using the R package “circlize” [123]. Genomic positions of genes and chromosome bands were retrieved from the UCSC genome browser, human genome version hg19. Detailed data are provided in Additional file 1: Table S1A, Additional file 2: Table S2A, and Additional file 3: Table S3A. These also include studies containing exclusively pediatric patients or patients with APL, which were not considered for this figure. Recurrently gained aberrations are shown in this graph irrespective of whether or not they were recurrently lost in other patients; information about recurrent loss at relapse is provided in Additional file 1: Table S1B, Additional file 2: Table S2B, and Additional file 3: Table S3B