Fig. 3

New findings on hematopoietic hierarchy and origin of hematopoietic stem cell by single-cell analysis. a Traditional step-down cell hierarchy model. b Single-cell SPADE hierarchy demonstrate early separation of MegE and lympho-myeloid lineage. c Transcriptional heterogeneity and cell hierarchy in myeloid progenitor populations. d Redefined model demonstrates two different development stage in the progenitor cell. e Tracing pre-HSC at single-cell level