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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: EPCR promotes breast cancer progression by altering SPOCK1/testican 1-mediated 3D growth

Fig. 5

Effects of SPOCK1 silencing in primary tumor growth and metastasis in 1833-derived xenograft models. a Outline of the orthotopic experiment to assess primary tumor growth. b Tumor volume measurements along the whole experimental period. c Weight of resected tumors at day 37 post-injection. d mRNA levels of SPOCK1 in resected tumors (n = 3 per group), assessed by RT-qPCR. e Outline of the intracardiac inoculation experiment to assess bone metastasis. f Number of mice and bones with metastases in each group. g BLI quantification in hind limbs at day 28 post-injection. h Tumor area quantification in H&E-stained bone sections. i Osteolytic bone area quantification in micro-CT scans from day 28 post-injection. j Representative images of BLI, micro-CT scans, and H&E-stained bone sections, from top to bottom, respectively. All data are mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001. ns, non-statistical significance

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