Fig. 6From: NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate KinaseSchematic model of NEK2-mediated aerobic glycolysis through splicing of PKM1/2. c-Myc enhances the transcription of NEK2 and hnRNPA1/2, then NEK2 and hnRNPA1/2 complex bind to the intronic sequences flanking exon 9 of PKM pre-mRNA to out splicing exon 10 result in elevated expression of PKM2 and increased aerobic glycolysisBack to article page