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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase

Fig. 3

NEK2 regulates aerobic glycolysis in myeloma cells. a GEP analysis of NEK2, HK2, ENO1, and LDHA on plasma cells derived from normal healthy donors (n = 22), MGUS patients (n = 44), low-, and high- (n = 305) risk MM patients (n = 46). b Real-time PCR was performed to test the expression of GLUT4, NEK2, HK2, ENO1, and LDHA in NEK2 silenced ARP1 and OPM2 MM cell lines, *p < 0.001. c, d Glucose uptake and lactate production were analyzed in NEK2 knocked down ARP1 MM cells cultured at normoxia (black column) or hypoxia (grey column), *p < 0.05

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