Skip to main content
Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Long-term immune reconstitution and T cell repertoire analysis after autologous hematopoietic stem cell transplantation in systemic sclerosis patients

Fig. 3

TCR-Vβ family expression and T cell receptor β-chain spectratyping before and at long-term after aHSCT. a Quantification of each TCR-Vβ family at baseline (white bars) and at long-term (dark bars) after aHSCT in 10 dcSSc patients. Data are presented as mean ± SD. There are no differences between the clinical groups. b TCR-Vβ chain third complementarity-determining region size distribution profile of selected families at baseline (pre, upper level) and at long-term time point (lower level) for representative dcSSc patients who underwent autologous hematopoietic stem cell transplantation. Left: Polyclonal distribution achievement at long-term time point post-HSCT from a skewed and disturbed repertoire at baseline (patient 3, group A, responder). Right: Sustained disturbed distribution at long-term time point post-HSCT from a previously skewed profile at baseline (patient 1, group B, non-responders or relapse or necessitating immunosuppression). c T cell repertoire diversity as measured by the percentage of polyclonal TCR-Vβ families in all 10 dcSSc patients at baseline and at long-term follow-up (at least 6 years) after aHSCT

Back to article page