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Table 3 Multivariate analyses of factors associated with OS and TTR

From: Monoacylglycerol lipase promotes progression of hepatocellular carcinoma via NF-κB-mediated epithelial-mesenchymal transition

 

OS

TTR

Variablesa

HR (95% CI)

P

HR (95% CI)

P

HBsAg (negative vs. positive)

 

NA

1.342 (0.700–2.573)

0.377

Liver cirrhosis (no vs. yes)

1.278 (0.795–2.053)

0.311

1.356 (0.855–2.149)

0.195

AFP (≤20 vs. >20 ng/ml)

1.487 (0.915–2.418)

0.110

 

NA

Tumor number (single vs. multiple)

1.642 (1.063–2.534)

0.025

1.671 (1.082–2.582)

0.021

Tumor size (≤5 vs. >5 cm)

2.712 (1.447–5.083)

0.002

1.874 (1.009–3.481)

0.047

Tumor encapsulation (complete vs. incomplete)

1.504 (0.988–2.289)

0.057

 

NA

Microvascular invasion (absent vs. present)

0.711 (0.385–1.315)

0.277

0.775 (0.419–1.436)

0.418

Edmondson grade (I–II vs. III–IV)

1.574 (0.989–2.504)

0.056

 

NA

TNM stage (I vs. II–III)

1.023 (0.444–2.358)

0.957

1.726 (0.687–4.340)

0.246

MAGL (low vs. high)

1.628 (1.020–2.597)

0.041

1.593 (1.011–2.510)

0.045

  1. OS overall survival, TTR time to recurrence, HR hazard ratio, CI confidence interval, HBsAg hepatitis B surface antigen, AFP alpha fetoprotein, TNM tumor node metastasis, MAGL monoacylglycerol lipase, NA not adopted
  2. aVariables were adopted for their prognostic significance by multivariate analysis using the Cox proportional hazards regression model
  3. Italic numbers means P < 0.05