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Fig. 7 | Journal of Hematology & Oncology

Fig. 7

From: Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graft-versus-host disease development

Fig. 7

Effect of BEZ235 in a murine model of GvHD. a Kaplan–Meier curve representing overall survival of the different experimental groups: TBI (n = 4), BM (n = 8), GvHD (n = 15), and GvHD + BEZ235 (n = 11). b Evolution of weight loss of transplanted mice (median weight in grams); #p < 0.05. c GvHD score of transplanted mice (median); #p < 0.05. d Histopathological analysis of skin, large bowel, and liver samples from the different experimental groups were obtained in the third week after transplantation and once treatment was completed (beyond 60 days after transplantation). Apoptotic bodies (yellow arrows), loss of crypts and caliciform cells (green arrows) in large bowel, and lymphocytic infiltration in periportal areas (black arrows) in the liver are indicated. Original magnification: ×200; insets: ×400

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