Fig. 6
Effect of BKM120 and BEZ235 on T cell tolerization. Percentage of IFN-γ secreting cells among lymphocytes pre-stimulated with allogeneic cells in the presence of different doses of BKM120 or BEZ235 and re-stimulated, in the absence of drugs, with the same allogeneic cells or with CMV-pp65. Every value was normalized to the number of IFN-γ secreting cells that had been pre-stimulated in the absence of drugs (0 μM) and subjected to the corresponding kind of re-stimulation. Results are means + SEM of three independent experiments. #p < 0.05 with respect to stimulated untreated samples (0 μM); n.s. non-significant differences with respect to stimulated untreated samples (0 μM)