Skip to main content
Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis

Fig. 5

MIIP competing with Rac1-GTP to bind the PAK1-binding domain. The results of our studies provide evidence that MIIP inhibited EC migration through reducing the formation of lamellipodia. MIIP may block Rac1 signaling pathway through competing binding to Rac1’s downstream effector PAK1, which resulted in decreasing formation of lamellipodia and then inhibiting EC cell migration

Back to article page