Fig. 2

Alantolactone induced the apoptosis and differentiation of leukemia stem-like cell line KG1a and primary AML cells. a The expression of CD34⁺CD38^– on the surface of KG1a cells by flow cytometry. The χ axis represented CD34-APC, and the Y axis represented CD38-AF488. b Alantolactone induced the differentiation of leukemia stem cells after 3 days treatment. c Alantolactone induced apoptosis of primary AML cells with a dose-dependent manner after the treatment of alantolactone for 18 h. Each point represents an AML specimen. d Alantolactone induced apoptosis with a dose-dependent manner in KG1a cells with the treatment of alantolactone for 24 h. Analysis results represented mean ± SD based on three independent experiments, **P < 0.01, ***P < 0.0001