Fig. 1
From: Silencing of GATA3 defines a novel stem cell-like subgroup of ETP-ALL
GATA3 mRNA expression in patient samples. a Affymetrix-based mean differential expression of GATA3 based on normalized expression values in normal controls (NC) and selected hematological disorders. Horizontal lines indicate mean GATA3 expression \( \pm \) s.e. Note the segmented y-axis. b RT-PCR-based analyses of GATA3 mRNA expression relative to Jurkat on a logarithmic scale revealed lower GATA3 expression in ETP-ALL (n = 70) than in non-ETP-ALL (n = 112) (4.82 vs. 6.29, p = 0.0005 indicated by asterisk). We identified a bimodal distribution of GATA3 expression by K-means clustering with a cutoff at a relative expression of 0.2 (indicated by the dotted line). The GATA3low cohort contained only cases with ETP-ALL (i.e., GATA3low ETP-ALL)