TTFT | OS | ||||
---|---|---|---|---|---|
Variable | N pts | HR (CI 95 %) | p | HR (CI 95 %) | p |
Binet stage B–C vs A | 39 vs 161 | 9.884 (5.939–16.450) | <0.0001 | 3.174 (1.677–6.007) | 0.0002 |
CD38 pos vs neg | 79 vs 121 | 4.097 (2.564–6.546) | <0.0001 | 3.123 (1.686–5.783) | 0.0001 |
IGVH mut vs unmut | 105 vs 91 | 5.584 (3.326–9.374) | <0.0001 | 3.667 (1.886–7.127) | <0.0001 |
11q22 deletion yes vs no | 20 vs 180 | 2.879 (1.528–5.426) | 0.0006 | 1.736 (0.739–4.078) | 0.2000 |
TP53 disruption yes/no | 19 vs 181 | 3.284 (1.867–5.781) | <0.0001 | 4.246 (2.076–8.687) | <0.0001 |
FISH int-unfav vs fav | 58 vs 142 | 2.605 (1.670–4.063) | <0.0001 | 2.432 (1.438–4.454) | 0.0029 |
Complex karyotype yes vs no | 28 vs 167 | 2.979 (1.756–5.056) | <0.0001 | 3.854 (1.961–7.578) | <0.0001 |
Mutations by NGS no/yes | 116 vs 84 | 2.835 (1.799–4.469) | <0.0001 | 2.171 (1.176–4.008) | 0.0130 |
Number of mutations by NGS | |||||
0 | 116 | 1 | <0.001 | 1 | 0.037 |
1 | 47 | 2.373 (1.369–4.112) | 0.002a | 1.936 (0.930–4.032) | 0.078a |
≥2 | 37 | 3.418 (2.009–5.759) | <0.001a | 2.466 (1.187–5.126) | 0.016a |
TP53 mut vs wt | 16 vs 184 | 2.804 (1.514–5.194) | 0.0010 | 2.793 (1.284–6.098) | 0.0069 |
NOTCH1 mut vs wt | 16 vs 184 | 2.353 (1.164–4.762) | 0.0141 | 2.646 (1.114–6.259) | 0.0219 |
SF3B1 mut vs wt | 15 vs 185 | 1.779 (0.886–3.571) | 0.1006 | 1.170 (0.419–3.268) | 0.7648 |
ATM mut vs wt | 10 vs 190 | 3.623 (1.715–7.633) | 0.0003 | 1.946 (0.686–5.525) | 0.2023 |
BIRC3 mut vs wt | 8 vs 192 | 0.817 (0.254–2.597) | 0.7246 | 1.099 (0.252–4.808) | 0.8998 |
MYD88 mut vs WT | 7 vs 193 | 1.758 (0.642–4.812) | 0.2724 | 1.505 (0.363–6.240) | 0.5733 |
PTEN mut vs WT | 7 vs 193 | 1.573 (0.574–4.310) | 0.3780 | 1.503 (0.363–6.224) | 0.5742 |
FBXW7 mut vs WT | 6 vs 194 | 1.820 (0.664–4.988) | 0.2441 | 1.445 (0.349–5.986) | 0.6134 |
POT1 mut vs WT | 5 vs 195 | 1.059 (0.259–0.321) | 0.9375 | 0.978 (0.352–4.768) | 0.9973 |
BRAF mut vs WT | 5 vs 195 | 7.730 (3.014–19.827) | <0.0001 | 2.126 (0.286–15.823) | 0.4610 |
ZMYM3 mut vs WT | 5 vs 195 | 0.484 (0.067–3.480) | 0.4710 | 2.336 (0.563–9.693) | 0.2434 |
OTHERS mut vs wt | 19 vs 181 | 1.036 (0.517–2.075) | 0.9205 | 0.898 (0.320–2.518) | 0.8381 |