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Table 3 Correlations between mutations by NGS analysis, FISH results, and karyotype complexity

From: Extensive next-generation sequencing analysis in chronic lymphocytic leukemia at diagnosis: clinical and biological correlations

 

FISH results

 

Complex karyotype

 

Fav

Int-unfav

No

Yes

p

No. of mutations by NGS no/1/≥2

94/28/20

22/19/17

0.001

104/36/27

9/11/8

0.011

TP53 WT/mut

135/7

49/9

0.012

158/9

22/6

0.003

NOTCH1 WT/mut

133/9

51/7

0.175

155/12

25/3

0.517

SF3B1 WT/mut

132/10

53/5

0.701

156/11

25/3

0.434

ATM WT/mut

137/5

53/5

0.133

161/6

24/4

0.018

BIRC3 WT/mut

140/2

52/6

0.003

161/6

26/2

0.381

MYD88 WT/mut

136/6

57/1

0.382

164/3

24/4

0.001

PTEN WT/mut

138/4

55/3

0.411

161/6

27/1

0.996

FBXW7 WT/mut

141/1

53/5

0.003

161/6

28/0

0.308

POT1 WT/mut

138/4

57/1

0.653

162/5

28/0

0.354

BRAF WT/mut

139/3

56/2

0.583

163/4

28/0

0.408

ZMYM3 WT/mut

138/4

57/1

0.653

163/4

27/1

0.716

Others WT/mut

129/13

49/6

0.192

149/18

24/4

0.587

  1. f female, fav favorable, int intermediate, m male, mut mutated, neg negative, pos positive, unfav unfavorable, unmut unmutated