Matched and mismatched unrelated donor compared to autologous stem cell transplantation for acute myeloid leukemia in first complete remission: a retrospective, propensity score-weighted analysis from the ALWP of the EBMT

Table 3 PS-weighted Cox analysis of transplant outcomes, adjusted for kind of conditioning and stem cell source

Type of transplant	NRM			RI			LFS			OS
Type of transplant	HR	95 % CI	p	HR	95 % CI	p	HR	95 % CI	p	HR	95 % CI	p
Global population
Auto-HSCT (reference)	1			1			1			1
10/10 UD-HSCT	3.1	2–4.7	<10⁻⁵	0.5	0.4–0.7	<10⁻⁵	0.7	0.6–0.9	0.0016	0.97	0.8–1.2	0.84
9/10 UD-HSCT	4.5	2.5–8.1	<10⁻⁵	0.5	0.3–0.8	0.0016	0.8	0.6–1.1	0.227	1.1	0.8–1.7	0.49
By cytogenetic risk
Good risk
Auto-HSCT (reference)	1			1			1			1
10/10 UD-HSCT	1.9	0.7–5.5	0.24	0.5	0.3–0.9	0.018	0.7	0.4–1.1	0.1	1.1	0.6–2	0.7
Intermediate risk
Auto-HSCT (reference)	1			1
10/10 UD-HSCT	3.6	2–6.4	<10⁻⁴	0.5	0.4–0.7	<10⁻⁵	0.7	0.6–0.9	0.01	0.98	0.7–1.3	0.9
9/10 UD-HSCT	9.4	4.9–18	<10⁻⁵	0.4	0.3–0.8	0.004	1.1	0.7–1.6	0.7	1.6	1.001–2.5	0.049
Intermediate wtFLT3
Auto-HSCT (reference)	1			1			1			1
10/10 UD-HSCT	2.8	0.8–9.8	0.11	0.5	0.29–0.98	0.04	0.6	0.4–1.1	0.10	0.95	0.53–1.7	0.88
Poor risk
Auto-HSCT (reference)	1			1			1			1
10/10 UD-HSCT	6.3	2.3–17.4	0.0004	0.5	0.3–0.7	0.0003	0.7	2.3–17.4	0.0004	0.9	0.6–1.2	0.4
9/10 UD-HSCT	11.7	4–34.7	<10⁻⁵	0.7	0.4–1	0.08	1.03	0.7–1.5	0.88	1.3	0.9–1.9	0.2

ISSN: 1756-8722