| Type of transplant |  | ||
---|---|---|---|---|
Variable | Auto-HSCT | 10/10 UD-HSCT | 9/10 UD-HSCT | p |
Number (total: 2879) | 1202 | 1302 | 375 | Â |
Gender, n (%) | Â | Â | Â | 0.046 |
 Male | 681 (57) | 694 (53) | 188 (50) |  |
 Female | 518 (43) | 608 (47) | 187 (50) |  |
WBC at diagnosis (×109/l), median (range) | 13.8 (0.3–820) | 10 (0.3–900) | 9.9 (0.2–790) | 0.32 |
 Missing | 592 | 308 | 99 |  |
Cytogenetic risk, n (%) |  |  |  | <10−4 |
 Good | 392 (33) | 137 (11) | 26 (7) |  |
 Intermediate | 624 (51) | 550 (42) | 165 (44) |  |
 Poor | 186 (16) | 615 (47) | 184 (49) |  |
Molecular aberrations, n (%) | Â | Â | Â | Â |
 NPM1 mutation |  |  |  | 0.001 |
 Absent | 64 (34) | 150 (49) | 41 (53) |  |
 Present | 124 (66) | 154 (51) | 37 (47) |  |
 Missing | 438 | 280 | 96 |  |
 FLT3-ITD |  |  |  | <10−4 |
 Absent | 159 (70) | 178 (48) | 48 (44) |  |
 Present | 68 (30) | 197 (52) | 61 (56) |  |
 Missing | 399 | 209 | 66 |  |
 CEBPA mutation |  |  |  | 0.07 |
 Absent | 40 (82) | 109 (90) | 33 (97) |  |
 Present | 9 (18) | 12 (10) | 1 (3) |  |
 Missing | 577 | 463 | 140 |  |
No. of induction courses to reach CR1, n (%) |  |  |  | <10−4 |
 1 | 617 (51) | 722 (56) | 187 (50) |  |
 More than 1 | 195 (17) | 408 (31) | 122 (33) |  |
 Missing | 390 (32) | 172 (13) | 66 (17) |  |
MRD status at transplant | Â | Â | Â | 0.53 |
 MRD negative | 361 (79) | 352 (73) | 81 (76) |  |
 MRD positive | 99 (21) | 132 (27) | 26 (24) |  |
 Missing | 742 | 818 | 268 |  |
Median age at transplant, years (range) | 49 (18–78) | 51 (18–76) | 49 (18–69) | 0.004 |
Median interval diagnosis transplant, days (range) | 158 (75–813) | 174 (66–997) | 177 (83–766) | <10−4 |
Median interval CR1 transplant, days (range) | 109 (21–365) | 115 (18–447) | 121 (21–348) | 0.41 |
 Missing | 390 | 172 | 66 |  |
Median year of transplant (range) | 2008 (05–13) | 2010 (05–13) | 2010 (05–13) | <10−4 |
Stem cell source, n (%) |  |  |  | <10−4 |
 BM | 53 (4) | 258 (20) | 58 (16) |  |
 PBSCs | 1149 (96) | 1044 (80) | 317 (84) |  |
TBI-including conditioning, n (%) |  |  |  | <10−4 |
 No | 1112 (93) | 936 (72) | 262 (70) |  |
 Yes | 85 (7) | 364 (28) | 113 (30) |  |
Conditioning intensity, n (%) | Â | Â | Â | Â |
 MAC | – | 619 (48) | 194 (52) |  |
 RIC | – | 677 (52) | 180 (48) |  |
Median follow-up, months (range) | 45 (1–128) | 36 (1–119) | 25 (1–113) |  |