Fig. 1From: Second-generation inhibitors of Bruton tyrosine kinaseThe structure of Bruton tyrosine kinase (BTK). BTK has a pleckstrin-homology (PH) domain, SH3 and SH2 (src-homology) domains, and a kinase domain. The BTK polypeptide has 659 amino acid residues with an approximate molecular weight of 76Â kDa. The C481S mutation in the kinase domain mediates resistance to ibrutinibBack to article page