Fig. 1

Proteasome subunit protein expression in relapsed childhood ALL and AML. Comparison of a constitutive subunit β1 b and constitutive subunit β5 expression for pre-B ALL (n = 46), T-ALL (n = 14) and AML (n = 12) patient samples and PBMCs from healthy adult volunteers (n = 5). c The ratio of paired subunits β1i/β1. d The ratio of paired subunits β5i/β5, within each patient sample for pre-B ALL (n = 46), T-ALL (n = 14) and AML (n = 12) patient samples. Protein expression was assessed by Western blotting and expressed as relative quantifications of subunit expression (ratio proteasome subunit/β-actin based on loading of 15 μg total protein, normalized to CEM). The line denotes the mean. Significant p values are noted (Mann-Whitney U test)