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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer

Fig. 6

t-BHQ activated NRF2 signaling and conferred chemo-resistance to platinum-based drugs. a, b t-BHQ induced the expression of NRF2 and NRF2-regulated genes at the mRNA and protein levels in H292 cells. c, d t-BHQ conferred chemo-resistance to platinum-based drugs in H292 cells. e, f t-BHQ induced the expression of NRF2 and NRF2-regulated genes at the mRNA and protein levels in SKMES-1 cells. g, h t-BHQ conferred chemo-resistance to platinum-based drugs in SKMES-1 cells. The results are presented as the mean ± SEM. *p < 0.001, **p < 0.05. Vec vector

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