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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer

Fig. 1

Identification of KEAP1 mutations and basal expression levels of NRF2-regulated genes in NSCLC. Sequencing of the KEAP1 gene led to the identification of G333C mutation in A549 cells (a) and the D236H mutation in H460 cells (b). The arrow indicates the mutant peak. c Characteristics of the four NSCLC cell lines and a description of the KEAP1 mutations. NA, no mutant domain. d Basal expression of KEAP1, NRF2, and NRF2-regulated genes in the four NSCLC cell lines

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