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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives

Fig. 2

Mechanisms and structures of histone lysine demethylases (KDM). a Mechanism of catalysis for FAD dependent KDM1 proteins (including LSD1 and 2); b The active site of LSD1 in complex with FAD and a histone H3 peptide (PDB: 2V1D). LSD1 is shown as a 50 % transparent electrostatic surface. The peptide is shown as a wire model (C atoms in green), with the K4M residue highlighted as a tube model; c Mechanism of catalysis for JmjC domain KDMs; d The active site of PHF8 in complex with Fe2+ (cyan sphere), an α-KG analog (brown) and a histone H3 peptide (green) (PDB: 3KV4)

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