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Table 2 Inhibitory activity (IC50, μM) against MAO-A and -B for compounds 14 and their selectivity indices for LSD1

From: Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia

  LSD1 MAO-A MAO-B Selectivity index
1 0.0098 17.5 34.2 >1700
2 0.077 120 480 >1500
3 0.035 7.3 16.3 >208
4 5.3 0.42 3.1 <0.58