Table 2 Inhibitory activity (IC50, μM) against MAO-A and -B for compounds 1–4 and their selectivity indices for LSD1
From: Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia
| Â | LSD1 | MAO-A | MAO-B | Selectivity index |
|---|---|---|---|---|
1 | 0.0098 | 17.5 | 34.2 | >1700 |
2 | 0.077 | 120 | 480 | >1500 |
3 | 0.035 | 7.3 | 16.3 | >208 |
4 | 5.3 | 0.42 | 3.1 | <0.58 |