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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia

Fig. 4

Combination of LSD1 and DOT1L inhibition caused synergistic effects against proliferation of MLL-rearranged leukemia cells. a Combination treatment of MV4-11 cells with compounds 2 and SYC-522 exhibited combination index (CI) values of 0.13–0.36. b Combination treatment of Molm-13 cells with compounds 1 and SYC-522 showed combination index (CI) values of 0.01–0.61. CI values <1 indicate synergism, while those =1 and >1 show additive effect and antagonism, respectively

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