Fig. 2
From: Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia
Dose-dependent biological activities of compounds 1 and 2 in MV4-11 cells. a 1 and 2 caused increased levels of H3K4me2, while these compounds seem not to affect H3K4me1 and me3 significantly. b 1 (upper) and 2 (lower panel) reduced gene expression of HoxA9 and Meis1 whose overexpression is characteristic to MLL-rearranged leukemia (* p < 0.05 with respect to the control). c 1 and 2 induced considerable amounts of apoptosis in 7 or 14 days