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Table 2 Brigatinib and lorlatinib in clinical development for non-small cell lung cancer

From: Second- and third-generation ALK inhibitors for non-small cell lung cancer

Trials

Agents

Patients

No.

ORR

PFS

Refs.

Phase I/II

(NCT01449461)

Brigatinib

Crizotinib-naive

Crizotinib-failure

with CNS metastases

7

65

38

7/7 (100 %)

45/65 (69 %)

14/38 (37 %)

56 weeks

47 weeks

97 weeks

[72]

Phase I/II

(NCT01970865)

Lorlatinib

Untreated

Failed 1 ALKi

N/A

N/A

N/A

[77]

  1. Abbreviations: N/A not applicable, ORR overall response rate, DOR duration of response, PFS progression-free survival, Ref reference, wks weeks, m months, ALKi ALK inhibitor