From: Second- and third-generation ALK inhibitors for non-small cell lung cancer
Trials
Agents
Patients
No.
ORR
PFS
Refs.
Phase I/II
(NCT01449461)
Brigatinib
Crizotinib-naive
Crizotinib-failure
with CNS metastases
7
65
38
7/7 (100Â %)
45/65 (69Â %)
14/38 (37Â %)
56Â weeks
47Â weeks
97Â weeks
[72]
(NCT01970865)
Lorlatinib
Untreated
Failed 1 ALKi
N/A
[77]