Fig. 4
From: Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence
BubR1 +/− SGO1 +/− compound mutations accelerate senescence. Primary MEFs of various genetic backgrounds (wild-type, BubR1 +/−, SGO1 +/−, and BubR1 +/− SGO1 +/−) were cultured in DMEM as described in the Methods section. MEFs of different passages were stained for SA-β-Gal. Percents of SA-β-Gal cells were recorded. Data summarized from three independent experiments are presented