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Table 1 The expression of CCR9 in cancer patients

From: CCR9 in cancer: oncogenic role and therapeutic targeting

Tumors

Cell type

Methods

Expression

References

T-ALL

PBMCs (n = 21)

FCM

91.9 %

[25]

Melanoma

Circulating tumor cells (n = 21)

FCM

57 %

[58]

Melanoma

Primary specimens (n = 32)

IHC

69.7 %

[59]

Melanoma metastasis

Small intestinal metastases (n = 102)

QPCR

86 %

[30]

Mediastinal large B cell lymphomas

Lymphoid tissue (n = 22)

IHC

90.9 %a

[60]

Large B cell lymphoma

Gastric extranodal diffuse lymphoma (n = 10)

IHC

58.33 %

[61]

Large B cell lymphoma

Gastrointestinal lymphoma (n = 41)

IHC

66 %b

[62]

Ovarian cancer

Cancer tissues (n = 43)

IHC

Significantly higher

[11]

Lung cancer

Lung biopsies (n = 50)

WB

1.2c

[63]

Hepatocellular carcinoma

Cancer tissues (n = 240)

IHC

55.8 %

[9]

Breast cancer

Moderately differentiated cancer tissues (n = 18)

IHC

50 %

[64]

Poorly differentiated cancer tissues (n = 18)

IHC

>75 %

Colon cancer

Adenomatous foci (n = 46)

IHC

2.26 ± 0.06d

[65]

Nasopharyngeal carcinoma

Carcinoma tissues (n = 42)

IHC

80.95 %

[66]

  1. FCM flow cytometry, PBMC peripheral blood mononuclear cell, QPCR quantitative polymerase chain reaction, IHC immunohistochemistry, WB western blot
  2. aProportion of positive tumor cells >50 % (20/22)
  3. b3+ CCR9 staining
  4. cControl tissue (n = 50), CCR9/β-actin <0.3
  5. dNormal colon epithelium had a mean staining intensity of 1.60 ± 0.04 (n = 55)