Fig. 5From: CCR9 in cancer: oncogenic role and therapeutic targetingThe mechanism of PE38-induced cell death. The immunotoxin is internalized when it binds with its specific receptor via the endolysosomal system to the Golgi, and it is further transported to the endoplasmic reticulum. Then, it can cause ADP ribosylation and elongation factor 2 inactivation to halt protein synthesis and eventually lead to cell deathBack to article page