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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Cancer-associated fibroblasts promote the progression of endometrial cancer via the SDF-1/CXCR4 axis

Fig. 2

CAFs comingled with HEC-1B cells, enhancing xenograft growth in nude mice. a, b Gross appearance of xenografts; HEC-1B cells were injected alone or were coinjected with various fibroblasts subcutaneously into the right flanks of 4-week-old nude mice, and xenografts were harvested after 40 days of growth in female hosts. c Average tumor weight in each group was evaluated at 40 days after injection. Error bars depict the standard error around the mean. ***P < 0.001. d Tumor volume was plotted on the indicated days. **P < 0.01; ***P < 0.001. e Sections of xenografts in different groups were submitted to immunohistochemistry using antibodies specific for human CK, vimentin, α-SMA, FAP, and FSP-1. Scale bar, 10 μm. f Expression of SDF-1α and CXCR4 in xenotransplanted tumors. g Western blot analysis detection of the phosphorylation of Ark and Erk protein expression in xenotransplanted tumors

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