Fig. 7
From: Roles of palmitoylation and the KIKK membrane-targeting motif in leukemogenesis by oncogenic KRAS4A
Contributions of palmitoylation and KIKK motif on leukemogenic potential of oncogenic KRAS4A. a Kaplan-Meier plot of cumulative survival of recipient mice transplanted with bone marrow cells infected by KRAS4AG12D (n = 5), KRAS4AG12D/C180S (n = 5), KRAS4AG12D/QIQQ (n = 11), KRAS4AG12D/C180S/QIQQ (n = 10) containing retroviruses. The MGI vector mice (n = 5) were observed as control. P values were determined by the log-rank test. **P < 0.01, ****P < 0.0001. b Immunophenotyping of the leukemic bone marrow cells isolated from the KRAS4AG12D, KRAS4AG12D/QIQQ, and KRAS4AG12D/C180S/QIQQ moribund mice by flow cytometry. The myeloid lineage markers include Gr-1 and Mac-1. All the cells are GFP positive gated. c Spleens from the mice of each group were shown as indicated. d Comparison of the spleen weights of each group mice. The data were presented as mean ± SEM. Student t test was used for the statistical analysis. **P < 0.01, ***P < 0.001; n = 3 in each group