Fig. 4

122-Exo sensitizes HCC cells to chemotherapeutic agents. a Cell viability assay on HepG2 and Huh7 cells by combined treatment with chemotherapeutic agents and AMSC-derived exosomes. b FITC-Annexin V/PI assay in exosome-treated HCC cells after 5-FU treatment. c FC analysis for Annexin V revealed an increase in apoptotic cells in 122-Exo-treated HCC cells after 5-FU or sorafenib exposure. d, e Cell cycle analysis revealed an increase in G0/G1 population in 122-Exo-treated HepG2 cells after 5-FU or sorafenib exposure. Data are presented as means ± SE. (*p < 0.05, **p < 0.01, n = 3). U.T untreated, 122-Exo AMSC-122-derived exosomes, 67-Exo AMSC-67-derived exosomes